Monday, December 3, 2012

Back Pain and MRIs


Back pain has reached epidemic proportions. The figures are sobering - there is a 70 percent chance that you will suffer from it at some point in your life and a 30 percent chance that you have had a back pain attack in the last 30 days. At any point of time about 1 percent of working age Americans are incapacitated by their lower lumbar regions and treatment is pretty much expensive accounting for $26 billion per year which is about 3 percent of the total health care spending. 
There has been a marked difference in the way we treat back pain with the discovery of MRI in the 1980s. Previous to that doctors had very little information or idea about the lower back region which is an exquisitely complicated body area full of tiny bones, ligaments, spinal discs and minor muscles. In the absence of information the only recourse that a doctor could take was to advice bed rest and surprisingly this proved to be a very effective remedy in that 90 percent of the patients got better within seven weeks. With the discovery of  MRI in the 1980s doctors have a stunningly accurate image of the lower back region but ironically that has made the problem worse. The machine simply gives too much of information and doctors as a result are unable to distinguish the significant from the irrelevant. The stunningly accurate images of the lower lumbar regions seen through an MRI are often misleading. The disc abnormalities which are apparent are seldom the cause of chronic back pain. In a 1994 an interesting study published in the New England Journal of Medicine, obtained images of the spinal regions of 98 people who had no history of back pain whatsoever. The images were then sent to doctors who didn't know that the patients weren't in pain. The result was shocking. The doctors reported that two-thirds of these normal patients exhibited "serious problems" such as bulging, protruding, or herniated discs. In 38 percent of these patients, the MRI revealed multiple damaged discs and nearly 90 percent of the patients exhibited some form of disc degeneration. These structural abnormalities are often used to justify surgery which sounds quixotic for people who have no history of back pain.
Similarly a large study published in the Journal of American Medical Association (JAMA) randomly assigned 380 patients with back pain to undergo two different types of diagnostic analysis. One group received x rays while the other group got diagnosed using MRIs which provided the doctors with much more detailed information about the underlying anatomy. Which group fared better? There was no difference in patient outcome. The vast majority of people in both groups got better - thus clearly more information didn't lead to less pain. But stark diff fences emerged when studies looked at how different groups were treated. Nearly 50 percent of the MRI patients were diagnosed with severe disc abnormalities requiring intensive medical interventions. These treatments were obviously more expensive and they had no measurable benefit.
Thus there is a danger of too much information and it can seriously interfere with our understanding. When the prefrontal cortex is overwhelmed, a person can no longer make sense of the situation. Correlation is confused with causation and people end up making theories out of coincidences. MRIs make it easier for doctors to see the lower lumbar region in vivid details highlighting all sorts of disc problems and so they reasonably conclude that these structural abnormalities are the cause behind back pain. They are usually wrong. Medical experts are now encouraging doctors not to order MRIs when evaluating back pain. A recent report in the New England Journal of Medicine, that MRIs should be used to image the back only under specific clinical circumstances - such as patients with a strong clinical suggestion of underlying infection, cancer or persistent neurologic deficit. In the latest clinical guidelines issued by the American College of Physicians and the American Pain Society, doctors were strongly recommended ... not to obtain imaging or other diagnostic tests in patients with non-specific low back pain. In too many cases expensive tests proved worse than useless and all the vivid imagery and detailing got in the way of effective diagnosis. Doctors thus performed better with less information.

 This interesting write up with some amount of editing on my part has been taken from the chapter titled "Choking on Thought" from,  How We Decide by Jonah Lehrer, Mariner Books, Houghton Mifflin Harcourt, Boston, New York, 2010.